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pInitiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:/ppPatients with hepatic insufficiency due to cirrhosisIn these patientsthe dosage of CRIXIVAN should be lowered because of decreased metabolism of CRIXIVANsee DOSAGE AND ADMINISTRATIONPatients with renal insufficiencyPatients with renal insufficiency have not been studied./ppKeep this medication in the container it came intightly closedand out of reach of childrenA desiccantdrying agentis included with your capsuleskeep this in your medicine bottle at all timesStore it at room temperature and away from excess heat and moisturenot in the bathroom/ppSee Table 9 for steps to prevent or manage these possible and known significant drug interactionsincluding dosing recommendationsConsider the potential for drug interactions prior to and during CRIXIVAN therapyreview concomitant medications during CRIXIVAN therapyand monitor for the adverse reactions associated with the concomitant medications./p

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