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pInfants whose mothers have taken losartan should be closely observed for hypotensionsee also section 4.3 and 4.4/ppAs a consequence of inhibiting the renin-angiotensin-aldosterone systemchanges in renal function including renal failure have been reported in patients at riskthese changes in renal function may be reversible upon discontinuation of therapysee section 4.4/ppSee ContraindicationsHyperkalemia with KsupplementsKsparing diureticsKcontaining salt substitutesMay be antagonized byand renal toxicity potentiated by NSAIDsincluding selective COX-2 inhibitorsmonitor renal function periodically in elderly and/or volume-depletedMonitor lithiumDual inhibition of the renin-angiotensin system with ARBsACEIsor aliskiren may increase risk of hypotensionhyperkalemiarenal function changesmonitor closelyAvoid concomitant aliskiren in renal impairmentCrClsupplementsKsparing diureticsKcontaining salt substitutesMay be antagonized byand renal toxicity potentiated by NSAIDsincluding selective COX-2 inhibitorsmonitor renal function periodically in elderly and/or volume-depletedMonitor lithiumDual inhibition of the renin-angiotensin system with ARBsACEIsor aliskiren may increase risk of hypotensionhyperkalemiarenal function changesmonitor closelyAvoid concomitant aliskiren in renal impairmentCrCl./ppIn patients with mild-to-moderate hepatic impairment the recommended starting dose of COZAAR is 25 mg once dailyCOZAAR has not been studied in patients with severe hepatic impairmentsee Use In Specific Populations and CLINICAL PHARMACOLOGY/ppCozaar is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure./p
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