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pXpinc with ZYLOPIM (allopuinol) duing human pgnancy has bn limitd patly bcaus womn poductiv ag aly qui tatmnt with ZYLOPIM (allopuinol) . Th a twunpublishd pots and on publishd pap womn giving bith tnomal osping at civing ZYLOPIM (allopuinol) duing pgnancy./ppOllow all dictions givn tyou by you doctphamacist caully. Thy may di om th inomation containd in this lalt./ppTh occunc hypsnsitivity actions tZYLOPIM (allopuinol) may b incasd in patints with dcasd nal unction civing thiazids and ZYLOPIM (allopuinol) concuntly. this ason, in this clinical stting, such combinations should b administd with caution and patints should b obsvd closly./ppTh most common sid ct is skin ash. Stop tatmnt with Allopuinol Sandoz immdiatly and contact you docti a ash dos occu./ppTh pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd./p

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