Specifically, altered concentrations of plasma proteins, declining hepatic function, and diminishing renal function among elderly are thought to prolong promethazine elimination.
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pHyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HClpromethazine hydrochlorideConsideration should be given to the discontinuation of promethazine HClpromethazine hydrochlorideand to the use of other drugs if these reactions occurRespiratory depressionnightmaresdeliriumand agitated behavior have also been reported in some of these patients./ppOral25 mg at bedtimeAlternatively12.5 mg may be administered before the evening meal and again at bedtime for antihistamine effects./ppSince recurrences of NMS have been reported with phenothiazinesthe reintroduction of promethazine HClpromethazine hydrochlorideshould be carefully considered./ppPromethazine suppositories are for rectal use onlyDo not try to swallow the suppositories or insert in any other part of your body./p
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promethazine is metabolized into sulfoxides of promethazine and n-demethylpromethazine after metabolism by liver and these metabolites are appearing in the urine.
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