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pDo not increase your dose or take this medication more often without your doctor’s approvalYour condition will not improve any faster and the risk of serious side effects may be increasedAlsodo not stop taking this medication without your doctor’s approval./ppGet emergency medical help if you have any signs of an allergic reaction to Prografhivesdifficult breathingswelling of your facelipstongueor throat./ppIncreased risk of cancerPeople who take PROGRAF have an increased risk of getting some kinds of cancerincluding skin and lymph gland cancerlymphomaIncreased risk of infectionPROGRAF is a medicine that affects your immune systemPROGRAF can lower the ability of your immune system to fight infectionsSerious infections can happen in people receiving PROGRAF that can cause deathCall your healthcare provider right away if you have any symptoms of an infectionincludingFever muscle aches sweats or chills warmredor painful areas on your skin cough or flu-like symptoms./ppCall your doctor right away if you have symptoms of a serious brain infectionsuch as a change in your mental stateproblems with speech or walkingor decreased visionThese symptoms may start gradually and get worse quickly./ppIt is recommended that patients initiate oral therapy with Prograf capsules if possibleInitial dosage and observed tacrolimus whole blood trough concentrations for adults are shown in Table 1 and for pediatrics in Table 3see Dosage In Adult KidneyLiverOr Heart Transplant Patientsfor blood concentration monitoring details in kidney transplant patientssee Dosage In Adult KidneyLiverOr Heart Transplant Patients/p
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thereafter, to achieve comparable mean prograf trough concentrations, on average, 25 higher total mean daily doses of prograf were required for prograf than for control.
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