In peri- and postnatal studies in rats, postnatal development at maternal doses of 40 or 50 mg kg day of doxazosin about 8 times human auc exposure with a 12 mg day therapeutic dose was delayed, as evidenced by slower body weight gain and slightly later appearance of anatomical features and reflexes.
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pTo avoid injury related to dizziness or faintingtake your first dose of doxazosin at bedtime unless otherwise directed by your doctorYour doctor will start this medication at a low dose and gradually increase your doseAny time your dose is increased or if you restart treatment after you have stopped ittake your first dose at bedtime unless otherwise directedFollow your doctor’s instructions carefully./ppOther medications can affect the removal of doxazosin from your bodywhich may affect how doxazosin worksExamples include azole antifungalssuch as itraconazoleketoconazoleboceprevirmacrolide antibioticssuch as clarithromycinHIV protease inhibitorssuch as lopinavirritonaviramong others./ppDoxazosin is used alone or with other drugs to treat high blood pressurehypertensionLowering high blood pressure helps prevent strokesheart attacksand kidney problemsThis medication works by relaxing blood vessels so blood can flow more easily./ppThis is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist./ppIf you have high blood pressurelifestyle changes that may help this medication work better include exercisingstopping smokingand eating a low-cholesterol/low-fat dietConsult your doctor for more details./p
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